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Serenin Max combines natural ingredients that work together to promote normal behavioral patterns and a healthy nervous system, particularly in times of stress.

60 Capsules Per Bottle
Product Code: NN121
Please call 1-800-721-1310 for more information on how to order.
Price for US Customers Only
Serenin Max provides natural ingredients to promote normal, calm behavioral patterns, particularly during times of stress, and to maintain a healthy nervous system and brain function supporting healthy cognition. These ingredients work together to achieve this calming effect and include:
  • St. John’s Wort extract, with active constituents hyperforin and hypericin, promotes healthy mentation and behavioral patterns by modulating serotonin, dopamine, and norepinephrine; reducing serotonin reuptake in the brain; and inhibiting GABA ligand binding.1
  • Eleuthero powder, an adaptogen, aids in the body’s ability to cope with environmental stress and anxiety by modulating the nitric oxide and cortisol production via the hypothalamic-pituitary axis.2
  • Passion flower extract, containing flavonoids and alkaloids, promote relaxation by inhibiting GABA uptake by nerve cell synapses.3
  • DL-phenylalanine is a form of an essential amino acid that promotes normal mood and behavior via two mechanisms. First, phenylalanine is a precursor for norepinephrine production and helps to maintain healthy amounts of the neurotransmitter. Second, phenylalanine is metabolized to the neuromodulator 2-phenylethylamine. An increase in the production of this metabolite helps to maintain normal mood and attention either by greater available concentration or by improvement of brain neuron receptor sensitivity.4
    NOTE: If pregnant or lactating, please discuss with your doctor before use.
  • 5-HTP (Griffonia simplicifolia seed), a metabolite produced from essential amino acid L-tryptophan and a direct precursor for serotonin production in the CNS that promotes serotonin production and thereby healthy behavioral responses in times of stress.5


1 Butterweck V, Wall A, Lieflander-Wulf U, Winterhoff H, and Nahrstedt A. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry. 1997; 30(Suppl 2): 117-124.

2 Wilson L. Review of adaptogenic mechanisms: Eleuthrococcus senticosus, Panax ginseng, Rhodiola rosea, Schisandra chinensis, and Withania somnifera. Australian Journal of Medical Herbalism. 2007; 19(3): 126-131.

3 Appel K, Rose T, Fiebich B, Kammler T, Hoffman C, and Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passifora incarnata L. Phytother Res. 2011; 25(6): 838-843.

4 Kravitz HM, Sabelli HC, and Fawcett J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath Assoc. 1984; 84(1 Suppl): 119-123.

5 Birdsall TC. 5-Hydroxytryptophan: A clinically effective serotonin precursor. Altern Med Rev. 1998; 3: 271-280.

  Daily Use
Children Under 16 Contact Natural Necessity
Adult Daily Use Take two (2) capsules as a dietary supplement, or as directed by a qualified health care professional.

Uso Sugerido: Tomar dos (2) capsulas diarias como suplemento nutricional o segun indicacion medical.

Serving Size: 1 Capsules
Capsules Per Bottle: 60
Ingredient Amount Per Serving
Vitamin B-6 (as pyridoxine HCl) 25 mg
Folate (as folic acid) 400 mcg
Vitamin B-12 (as cyanocobalamin) 200 mcg
Magnesium (as magnesium oxide) 100 mg
Selenium (as selenium amino acid chelate) 70 mcg
5-HTP (L-5-hydroxy-tryptophan (Griffonia simplicifolia) (seed) 25 mg
DL- Phenylananine 40 mg
Eleuthero powder (Eleutherococcus senticosus)(rhizome) 70 mg
Inositol 100 mg
L-Tyrosine 10 mg
St. John's Wort extract (Hypericum perforatum)(flower heads)(std. for 0.3% Hypericin (1.8 mg)) 600 mg
Passion Flower extract (Passiflora incarnata) (aerial parts)(std. for >3.5% flavonoids as Isovetexin (1.75 mg)) 50 mg
Other Ingredients: Rice flour, Gelatin, Magnesium stearate, Amorphous silica gel, Maltodextrin.

Contains: corn, rice, animal products (beef, pork).
Extra Information:
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten or corn. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.