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Research Area

Below is the latest nutraceutical research using products and ingredients found in products. The articles below are separated into two categories:

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Product Research
Below are studies using supplements. Please click on each study to expand and learn more. The articles referenced in this research section are for reference only and do not claim to support any product.
Pilot Study: Effect of PDS-2865® on Natural Killer Cell Cytotoxicty
The hemicellulose preparation, (Natramune™ (PDS-2865®), Increases Macrophage Phagocytosis and Nitric Oxide Production and Increases Circulating Human Lymphocytes Levels
Evaluation of Imuno-2865® on General Rehabilitation Outcomes and Cytokine Profile Analysis in Abandoned Neonatal Harbor Seals (phoca vitulina) and Malnourished Weanling Elephant Seals (Mirounga angustirostris)
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A Placebo Controlled Masked Study Using Antioxidant Blend OCU-GLO Rx™ - Performed By Dr. David Williams
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Imuno-2865® and PureWay-C®
Natramune™ and PureWay-C® Reduce Xenobiotic-Induced Human T-cell a5b1 Integrin-Mediated Adhesion to Fibronectin
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A Novel Vitamin C Preparation Enhances Neurite Formation and Fibroblast Adhesion and Reduces Xenobiotic-Induced T-cell Hyperactivation
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Lecithin, Omega-Max, Alpha Lipoic Acid, Artichoke & Milk Thistle
Alternative Treatment Options For Managing Hepatic Lipidosis In An Atlantic Ridley Sea Turtle (Lepidocheyls kempii)
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PolicosanolPlus® and Neuroprevin™ Enhance Neurite Regeneration and Prevent Neurite Degeneration: A Dietary Supplement for Nerve Repair, Prevention and Reduction of Neurodegenerative Disorders
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Research on ingredients in products

The articles below are studies of the ingredients that are in supplements. Click on each article title to learn more. The articles referenced in this research section are for reference only and do not claim to support any product.

Grapeseed Extract
Omega-3-Fatty Acids
Vitamin C
Vitamin E
Epigallocatechin Gallate (Green Tea Extract)
Alpha Lipoic Acid
Vitamin B Blend
Will Ocu-GLO™ help get rid of my dog's cataracts?
Is Ocu-GLO™ safe for cats?
What Is Glaucoma?
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Assessment of Methylsulfonylmethane (MSM) on the Development of Osteoarthritis (OA): An Animal Study
The Effect Of Distilled Methylsulfonylmethane (MSM) on Human Chondrocytes in vitro
Treatment of Low Back Pain Exacerbations With Willow Bark Extract: A Randomized Double-Blind Study.
Bromelain Reduces Mild Acute Knee Pain and Improves Well-Being in a Dose-Dependent Fashion in an Open Study of Otherwise Healthy Adults.
Patented Antiinflammatory Plant Drug Development From Traditional Medicine.
Acetyl-11-Keto-Beta-Boswellic Acid, A Constituent Of A Herbal Medicine From Boswellia Serrata Resin, Attenuates Experimental Ileitis.
The Influence of Glucosamine on the Antiexudative Effect of Nonsteroidal Anti-Inflammatory Agents
The Clinical Effectiveness Of Glucosamine And Chondroitin Supplements In Slowing Or Arresting Progression Of Osteoarthritis Of The Knee: A Systematic Review And Economic Evaluation.
Glucosamine and Chondroitin Sulfate As Therapeutic Agents for Knee and Hip Osteoarthritis.
Efficacy of Methylsulfonylmethane (MSM) in Osteoarthritis Pain of the Knee
Plasma Antioxidant Levels in Eastern Screech Owls (Megascops asio) After Supplementation
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Serenin Vet™
Behavior Problems in Geriatric Pets
Pharmacological Studies In An Herbal Drug Combination of St. John's Wort (Hypericum perforatum) and Passion fower (Passifora incarnata): In Vitro and In Vivo Evidence of Synergy Between Hypericum and Passifora in Antidepressant Pharmacological Models
Effects of Various Eleutherococcus senticosus Cortex on Swimming Time, Natural Killer Activity and Corticosterone Level in Forced Swimming Stressed Mice
Hypericum Perforatum Treatment: Effect on Behaviour and Neurogenesis in a Chronic Stress Model in Mice
Suppression of Aggression in Rainbow Trout (Oncorhynchus mykiss) by Dietary L-tryptophan
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SHaNa Vet™
Antiviral Activity of 1-Docosanol, An Inhibitor of Lipid-Enveloped Viruses Including Herpes Simplex
Antifungal Activity of the Essential Oil From Calendula Officinakis L. (Asteracae) Growing in Brazil
The Anti-Herpes Simplex Virus Activity of N-Docosanol Includes Inhibition of the Viral Entry Process
Evaluation of Triacontanol-Containing Compounds as Anti-Inflammatory Agents Using Guinea Pig Models
Triacontanol Inhibits Both Enzymatic and Nonenzymatic Lipid Peroxidation
Potentiation of Antifungal Effect of Amphotericin B By Squalene, An Intermediate For Sterol Biosynthesis
Differential Effect of Lipoxygenase on Aflatoxin Production by Aspergillus spp.
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Alpha Lipoic Acid
Acetyl-L-Carnitine Lipoic Acid Supplements
A Current Update on the Use of Alpha Lipoic Acid in the Management of Type 2 Diabetes Mellitus
Alpha-lipoic Acid Supplementation and Diabetes
Acetyl-L-carnitine and a-Lipoic Acid Supplementation of Aged Beagle Dogs Improves Learning in Two Landmark Discrimination Tests
New Metabolic Pathways of a-Lipoic Acid
Alpha-Lipoic Acid as a Biological Antioxidant
Therapeutic Agents for the Treatment of Cognitive Dysfunction Syndrome in Senior Dogs
Alpha Lipoic Acid, A Powerful and Unique Antioxidant: Preliminary Results Following Administration of ALA to Pinnipeds
Pharmacokinetics of Orally Administered DL-a-lipoic Acid in Dogs
Therapy and Outcome of Suspected Alpha Lipoic Acid Toxicity in Two Dogs
Short-term Supplementation with Acetyl-L-Carnitine and Lipoic Acid Alters Plasma Protein Carbonyl Levels But Does Not Improve Cognition in Aged Beagles
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Relationship Between Plasma Fatty Acid Profile and Antioxidant Vitamins During Normal Pregnancy
The Importance of Antioxidant Micronutrients in Pregnancy
Essential Fatty Acids in Mothers and Their Neonates
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Spirulina in Pregnancy & Lactation
Availability of Iron to Rats from Spirulina, a Blue-Green Alga
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Thiamine Deficiency in a Collection of Pacific Harbor Seals
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Vitamin D in Pregnancy and Lactation: Maternal, Fetal, and Neonatal Outcomes From Human and Animal Studies
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Vitamin E: Maternal Concentrations Are Associated With Fetal Growth
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Studies conducted to support Marine Mammal Nutrition

The studies below have been conducted to support understanding of marine mammal nutrition. Click on each article title to learn more. The articles referenced in this research section are for reference only and do not claim to support any product.

Multimodal Approach to Regurgitation in a California Sea Lion (Zalophus californianus)
Nutritional Analysis of Frozen Canadian Capelin (Mallotus villosus), Atlantic Herring (Clupea harengus), and Canadian Lake Smelt (Osmerus mordax) Over A 9 Month Period of Frozen Storage
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Presented at the 2014 American College of Veterinary Ophthalmology Meeting

Glaucoma is a neurodegenerative disease, affecting optic nerve and retinal ganglion cells. The pathogenesis of glaucoma involves various factors, one of which is hypothesized to be oxidative stress. Strategies to reduce oxidative stress help support eye health in dogs with glaucoma, including supplementation with Ocu-GLO™.

This clinical research study, presented last month at the 2014 American College of Veterinary Ophthalmologists Annual Conference by Dr. Corey Schmidt of Colorado State University, shows that Ocu-GLO™ significantly decreased oxidative stress and the intraocular pressures (IOPs) of 8 month old D2 mice compared to untreated D2 mice (D2 mice develop genetic glaucoma). Also, density image analysis revealed significantly more malondialdehyde (MDA) and nuclear transcription factor (nrf2) staining in the ganglion cell layer (GCL) of untreated D2 mice compared to the control and treated D2 mice. MDA is a marker for lipid peroxidation of polyunsaturated fatty acids, and is used to measure the level of oxidative stress present. Nrf2 regulates the expression of antioxidant proteins that protect against oxidative damage. In untreated D2 mice, IOPs and also oxidative stress markers in the GCL neurons were increased by 8 months of age compared to the controls. The oxidative stress in the treated eyes was almost completely halted. These results suggest that the elevations in IOP and changes in oxidative stress present in untreated D2 mice were reduced by feeding Ocu-GLO™.

While Ocu-GLO™ has been a retail nutraceutical product for 5 years, it previously existed for 3 years as a compounded prototype and was dispensed for patients of veterinary ophthalmologists Carmen Colitz and Terri McCalla as part of a clinical study. During 8 years of clinical experience with Ocu-GLO™, Drs. Colitz and McCalla have noted clinical benefits in patients with glaucoma, progressive retinal atrophy (PRA), senile retinal degeneration, uveitis regardless of underlying cause, mild keratoconjunctivitis sicca, immune-mediated blepharitis/conjunctivitis, and in pre- and post-operative cataract surgery patients. Additionally, dogs with PRA and also most diabetic dogs placed on Ocu-GLO™ prior to the development of significant cataract formation were found to have reduced incidence of cataractogenesis (PRA causes secondary "toxic" cataracts to form).

Ocu-GLO™ is also recommended as a lifetime supplement for dogs of breeds (and mixed breeds) at risk for developing ocular disease. Breeds at risk for developing primary (inherited) glaucoma include: Boston Terrier, Basset Hound, Cocker Spaniel, Jack Russell Terrier, Shih Tzu, Chow Chow, Shiba Inu, and Arctic Circle breeds (such as the Siberian Husky and Norwegian Elkhound).

Dr. Carmen Colitz is a board certified veterinary ophthalmologist with a PhD in Comparative and Experimental Medicine.

A Placebo Controlled Masked Study Using Antioxidant Blend OCU-GLO Rx™.

(DL Williams,1, CMH Colitz, 2, 1) Department of Veterinary Medicine, University of Cambridge UK, 2 Animal HealthQuest Solutions, LLC, USA)

Purpose. To evaluate Ocu-GLO™ an orally administered antioxidant/vitamin blend including the aldose reductase inhibitor alpha lipoic acid (ALA), to prevent diabetic cataracts in dogs.

Methods. 30 dogs diagnosed with diabetes mellitus, but without blinding lens changes, seen by DLW in the Department of Veterinary Medicine or in first opinion clinics visited though his ambulatory referral service, were randomly assigned to two groups. One group received Ocu-GLO™ daily PO. The other received placebo, containing the vitamin mix alone, daily PO. All dogs received a full ophthalmic examination and lens clarity was recorded photographically using a Genesis D fundus camera at +10D after pharmacological mydriasis. Dogs were followed for up to one year with examinations monthly. Duration of time without changes in lens opacification was documented for each dog and the two groups compared using Kaplan Meier survival curve statistics.

Results. Mean time without change in lens opacification was 136±66 days with Ocu-GLO™ and 64±24 days in the placebo group. Median duration without lens change was 112 and 65 days, respectively, this difference being statistically significant at p=0.0007. Nine of 15 dogs taking the placebo developed significant cataract while only 3 of 15 dogs taking Ocu-GLO™ developed significant cataract. These three dogs did not receive daily Ocu-GLO™ as directed due to unrelated illness or owner non-compliance.

Conclusion. This small preliminary study demonstrates that oral Ocu-GLO™ has beneficial effects in preventing cataract formation in dogs with diabetes mellitus.